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A "most promising" AIDS vaccine clinical trial in the United States declared a failure
On September 18, 2007, the U.S. faced a major setback in the fight against AIDS as a highly anticipated clinical trial for what was considered one of the most promising HIV vaccines was officially declared a failure. The Step trial, initiated in 2004 by Merck, the National Institute of Allergy and Infectious Diseases (NIAID), and the HIV Vaccine Alliance, had generated significant hope among researchers and the public alike. However, after a mid-term review published in *Science*, it was revealed that the vaccine failed to prevent infection or reduce viral load in those already infected.
Peggy Johnston, who led the AIDS Vaccine Program at NIAID, expressed deep disappointment, calling the news "shocking" and stating that it "ruined our hopes." Sarah Alexander, a spokesperson for the trial network, echoed similar sentiments, emphasizing the emotional toll on the scientific community. For the pharmaceutical industry, the failure marked a difficult moment, raising concerns about future investment in AIDS vaccine research.
Anthony Fossey, director of NIAID, warned that this setback could lead to a slowdown in the field, as companies may become more cautious before committing resources. As one industry insider noted, "People will be scratching their heads and asking for more solid scientific evidence before pouring money into such projects."
Despite the discouragement, experts emphasized that the trial provided valuable insights, and the knowledge gained would still contribute to future efforts in developing an effective HIV vaccine. The Step trial, though unsuccessful, remains a critical chapter in the ongoing battle against the global HIV/AIDS epidemic.