Release date: 2007-11-30 An experimental study has shown that the combination of Xuebijing injection and prostaglandin E1 can significantly improve the pathological changes in rats with experimental pulmonary fibrosis, slowing down the disease's progression. The underlying mechanism may involve reducing inflammation and fibrotic lesions by suppressing the expression of TNF-α and TGF-β1, thereby decreasing early inflammatory responses and collagen production. Pulmonary fibrosis, also known as interstitial pneumonia (IIP) or fibrous alveolitis (CFA), typically begins with inflammation of the alveolar walls, progresses to diffuse interstitial fibrosis, and eventually leads to alveolar wall fibrosis. High-resolution CT (HRCT) scans often reveal fine, reticular nodules in both lung fields, particularly in the lower lobes. The study, published in the March issue of the Chinese Journal of Emergency Medicine, involved a one-time intratracheal injection of bleomycin to induce pulmonary interstitial fibrosis in rats. The animals were divided into six groups, and after sacrifice, their lung tissues were examined for weight, wet lung coefficient, histopathological changes, hydroxyproline levels, and immunohistochemical staining for TGF-β. Bronchoalveolar lavage fluid (BALF) was collected and analyzed for TNF-α using ELISA. Researchers from the First Affiliated Hospital of Tianjin First Central Hospital, including Li Zhijun, found that the lung injury in the treatment groups was less severe, especially in those receiving combined traditional Chinese and Western medicine. The group treated with both Xuebijing and prostaglandin E1 showed the lowest hydroxyproline content in lung tissue, indicating reduced fibrosis. This group also exhibited significant suppression of TNF-α and TGF-β1 expression compared to other treatment groups. These findings suggest that the combination therapy effectively alleviates experimental pulmonary fibrosis in rats by targeting inflammatory pathways and fibrotic processes. The results highlight the potential of integrating traditional Chinese medicine with modern pharmacological treatments in managing this complex condition. As research continues, such combinations may offer new therapeutic strategies for patients suffering from pulmonary fibrosis. ——Midi Medical Network Anesthesia Breathing Circuit Sterilizer Anesthesia Breathing Circuit Sterilizer,Hydrogen Peroxide Disinfection Machine,Hydrogen Peroxide Sterilizer,Anesthesia Machine Ventilator JIANGSU JIANLAIBANG MEDICAL EOUIPMENT CO.,LTD , https://www.jsjlbmed.com
Experimental study on prevention and treatment of acute pulmonary fibrosis