Release date: 2007-11-30

A recent study published in the Chinese Journal of Emergency Medicine explored the potential of Xuebijing injection combined with prostaglandin E1 in the prevention and treatment of acute pulmonary fibrosis. The research, conducted by a team including Li Zhijun from the First Affiliated Hospital of Tianjin First Central Hospital, aimed to evaluate the effectiveness of this combination therapy in an experimental rat model of pulmonary interstitial fibrosis. The researchers used a single intratracheal administration of bleomycin to induce lung fibrosis in rats. The animals were divided into six groups, and after sacrifice, various parameters were analyzed, including lung weight, wet lung coefficient, histopathological changes, hydroxyproline levels, and levels of inflammatory markers such as TNF-α and TGF-β1. The results showed that all treatment groups exhibited reduced lung injury compared to the control group. However, the group receiving both Xuebijing injection and prostaglandin E1 showed the most significant improvement. This combination therapy was found to lower hydroxyproline content, indicating reduced collagen deposition. Additionally, it significantly suppressed the expression of TNF-α and TGF-β1, two key mediators of inflammation and fibrosis. Pulmonary fibrosis, also known as interstitial pneumonia or fibrous alveolitis, is characterized by progressive scarring of the lung tissue. In the early stages, it involves inflammation of the alveolar walls, while in later stages, it leads to fibrosis of the alveolar walls. High-resolution CT scans often reveal fine reticular nodules in the lower lung fields. This study highlights the potential of integrating traditional Chinese medicine with modern pharmacological treatments to manage pulmonary fibrosis. By targeting inflammatory pathways and reducing fibrotic responses, Xuebijing injection combined with prostaglandin E1 may offer a promising therapeutic approach for patients suffering from this condition. ——Midi Medical Network

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