Damocles Sword hanging over the head of humans - organic pollutants

Author: Millipore water market

In recent years, pesticides represented by organic phosphorus and organic chlorine, veterinary drugs represented by lean meat, malachite green, and nitrofuran, as well as organic pollutants such as polychlorinated biphenyls and acrylamides, have gradually become supervised and tested. The focus and hotspots of research institutions. These former "darlings" have been widely used in the rapid development of industrial and agricultural modernization due to their effects of increasing production, increasing efficiency, and treating, and have even been promoted as scientific research results. However, more frequent drug poisoning and food safety incidents indicate that these highly toxic, carcinogenic, teratogenic organic pollutants can still pass through raw materials at low doses (ppm-ppb level) and even trace (ppt) levels. The packaging, environment, water bodies and other ways seriously damage human health. To this end, it is urgent for regulatory, scientific research institutions and production units to prevent various organic pollutants from threatening human life through continuous improvement of detection methods.

The organic detection methods promulgated in the literature reports and standards mainly include high performance/ultra performance liquid chromatography (HPLC/UPLC), liquid chromatography-mass spectrometry (LC-MS), gas chromatography-mass spectrometry (GC-MS). , spectrophotometry, enzyme-linked immunosorbent assay (ELISA) and polarography, etc., these methods improve the detection limit of organic pollutants (ppb-ppt level) and sensitivity, while purifying the sample pretreatment process Higher standards, purity of standard and mobile phases, cleanliness of blank samples, etc.; on the other hand, high-speed, high-efficiency, high-precision instruments also require more pure samples and reagents to ensure their normal operation and longevity. . Water is the most widely used reagent in the laboratory and must be a top priority.
Milli-Q ® ultrapure water, which has become the industry standard for a long time, has always been a quality solution for the industry's advanced detection technology. Modern scientific research places higher demands on the sensitivity of organic and biochemical molecular detection. Obviously, chromatographic techniques have correspondingly increased the demand for high quality ultrapure water, especially in mobile phases, buffers, blanks, sample dilution, glass container cleaning, and extraction. Millipore's newly developed LC-Pak produces ultra-pure water with ultra-low organic content to solve the organic interference problem of most organic analysis.

Figure 1. Results of LC-MS analysis of five different sources of ultrapure water. 60 ml of sample water from different sources was enriched and eluted by C18 reversed-phase silica gel column and analyzed by LC-MS (PDA detector, single quadrupole detector). The result was that the water quality of LC-Pak was higher or better. bottled water.

In order to meet the research needs of trace organic pollutants, Millipore has developed a new ultra-pure water terminal filter LC-Pak. The terminal filter is mainly composed of purified C18 reverse phase silica gel, which effectively removes various organic pollutants by hydrophobic action. LC-Pak can be configured with Milli-Q water handle (Q-POD ® ) water outlet or any Millipore I grade water purification system (Milli-Q, Direct-Q ® , Synergy ® or Simplicity ® system). When the influent TOC < 5 ppb, LC-Pak can produce at least 500 liters of ultrapure water suitable for trace organic analysis for HPLC/UPLC/LC-MS water. Effectively improve the baseline drift caused by excessive TOC, ghost peaks, insufficient sensitivity, and blockage of the column.

LC-Pak terminal filter parameter specification sheet

About LC-PAK Terminal Filter
LC Pak is a terminal filter developed by Millipore to meet the needs of UPLC, LC-MS, LC-MS/MS trace and ultra-trace analytical water. The filter can be installed in the outlet of ultrapure water system, such as Milli. -Q, Direct-Q, Synergy, Simplicity, etc.
The LC-Pak can be matched to a Milli-Q water intake arm (Q-POD) outlet or to any Millipore I grade water purification system (Milli-Q, Direct-Q, Synergy or Simplicity system). When the TOC of the influent water is <5 ppb, the LC-Pak can produce at least 500 liters of ultrapure TM water suitable for trace organic analysis. Each LC-Pak comes with a warranty.

Source: Millipore China Blog http://blog.milliporechina.com/entry/LC-Pak1.html


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