Two key kinases regulate mitosis in eukaryotes

Two key kinases regulate mitosis in eukaryotes

August 21, 2018 Source: Science and Technology Daily

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Since the first observation of mitosis under the microscope more than a century ago, its beauty, complexity and importance to the life cycle of eukaryotes have attracted the attention of biologists and doctors. The key factors controlling eukaryotic mitosis are mainly through protein phosphorylation and regulation of degrading enzymes. Researchers at Vladimir Djokov, National Center for Cancer Research, St. Petersburg, Russia, discussed the mechanisms by which only a few protein kinases control different mitotic events in different time and space settings. The double-layer kinase consisting of two kinases, Aurora and PLK1, forms a signaling cascade that plays a central role in regulation, and this mode of action is even suitable for a wider range of mitotic networks.

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